In today's global fight against COVID-19, vaccination is also a form of protection. So, do you know how vaccines are made? Follow PreFluid peristaltic pump manufacturers to learn about it!
The general vaccine preparation process is divided into seven steps: cell culture, virus culture, inactivation, proportioning, filling and packaging.
1. Cell culture: Cell culture refers to Vero cell culture, so that Vero cells can proliferate rapidly in a certain formula of medium to prepare for subsequent virus culture.
2. Virus culture: The raw material of inactivated vaccine is virus, and a large amount of virus needs to be cultured in order to obtain vaccine. Vero cells are the preferred substrate for virus culture because of their ability to divide multiple times without aging.
3. Virus inactivation: The inactivation here makes the virus lose its pathogenicity and reproductive ability. This process is carried out in a specific bioreactor by injecting a number of special inactivating agents through biological reaction to achieve the purpose of inactivation and generate virus inactivation solution. And this process needs the whole channel closed, can achieve this effect of intelligent use of peristaltic pump liquid transfer transmission.
Do you know how vaccines are made
4. Purification of inactivated solution: The inactivated solution is gradually concentrated through filtration technology such as pipeline and screen, and the inactivated agent and other impurities are removed successively.
5. Drug and liquid ratio: The vaccine stock solution, adjuvant, diluent, etc. are evenly mixed together in proportion to become the semi-finished product of the vaccine we receive, and then the semi-finished product is tested.
6. Filling of liquid medicine: The containers for filling liquid vaccine are generally: celine bottles and prefilled syringes. We take Syrinx bottles as an example. Since Syrinx bottles are not sterile bottles, it is necessary to wash bottles and sterilize them at high temperature before filling semi-finished products, including ultrasonic pre-cleaning, high temperature steam condensate water washing the inner and outer walls, compressed air spraying and drying at high temperature of 350℃. Finally, the filling type peristaltic pump is used for accurate filling to ensure the purity of each bottle of vaccine and the accuracy and consistency of the dose of liquid medicine.
7. Finished product packaging: On the packaging line, the camera for lamp inspection takes photos at different angles and under background light to ensure that no impurities are mixed in the bottle, the sealing plug is in accurate position, and the bottle body has no scratches. Imperfect products will be expelled from the list here.
Next, a label is affixed with the product name and lot number, and each box also has a unique traceability code on it. When it was made, where it was sent, and by whom it was inoculated, this number can be quickly traced.
PreFluid focuses on providing professional peristaltic pump solutions for all kinds of global food, pharmaceutical, chemical, environmental protection and other enterprises. The company's products cover multiple series and models. Whether from function, appearance, volume, or performance, price, service, Puri fluid can meet the specific application needs of customers. To provide a variety of standard application solutions for customers to choose or to provide customers with customized service solutions to meet the different application needs of customers.